Order of the Stick

Order of the Stick.

Gaming humor/plot webcomic. Started in 2003. Probably digitally drawn. Creator: Rich Burlew.

OotS (as it's known) may draw its setting from D&D - in fact, Mr. Burlew works for the fellows who make D&D - but the humor, for the most part, is easily seen by anyone who reads it, regardless of their background. Due to the importance of the plot, it's almost certainly best to start at the beginning, but the current comic (as of this posting) can be found here.

(Note: There are currently two webcomics on the site initially linked to: Order of the Stick, and Erfworld. Erfworld - which I would also recommend - is drawn by a different author, started in 2006 (drawn to the site by the success of Oots), and is unconnected except by webhost and intended audience. I may review it at a later date.)